Boronic acid, B-(3-chloro-4-propoxyphenyl)-

Boronic acid, B-(3-chloro-4-propoxyphenyl)- - Names and Identifiers

Name	3-Chloro-4-propoxyphenylboronic acid
Synonyms	3-Chloro-4-propoxyphenylboronic acid 3-Chloro-4-propoxybenzeneboronic acid 1-(2-chlorophenoxy)propan-2-ylboronic acid Boronic acid, B-(3-chloro-4-propoxyphenyl)- Boronic acid, (3-chloro-4-propoxyphenyl)- (9CI)
CAS	480438-57-1
InChI	InChI=1/C9H12BClO3/c1-2-5-14-9-4-3-7(10(12)13)6-8(9)11/h3-4,6,12-13H,2,5H2,1H3

Boronic acid, B-(3-chloro-4-propoxyphenyl)- - Physico-chemical Properties

Molecular Formula	C9H12BClO3
Molar Mass	214.45
Density	1.23±0.1 g/cm3(Predicted)
Melting Point	143-148°C(lit.)
Boling Point	364.7±52.0 °C(Predicted)
Flash Point	174.4°C
Vapor Presure	5.85E-06mmHg at 25°C
pKa	7.69±0.17(Predicted)
Storage Condition	2-8°C
Refractive Index	1.531

Boronic acid, B-(3-chloro-4-propoxyphenyl)- - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3

Boronic acid, B-(3-chloro-4-propoxyphenyl)- - Introduction

The acid is an organic compound whose chemical formula is C9H12BClO3. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: acid is a white crystalline solid.
-Solubility: It can be dissolved in water, but also soluble in organic solvents such as methanol or dichloromethane.
-Melting point: Its melting point is about 127-129°C.
-Stability: It is relatively stable under conventional experimental conditions.

Use:
Cr acid can be used as a reagent and catalyst in organic synthesis. It is often used in the synthesis of aromatic compounds, especially plays an important role in Suzuki-Miyaura cross-coupling reactions. Organic halides can be catalyzed by coupling reactions with aromatic boronic esters to produce new organic compounds.

Preparation Method:
The method for preparing fluorene acid is generally obtained by reacting phenylboronic acid with 3-chloro-4-propoxybenzene phenol. Specific steps are as follows:
1. Mix phenylboronic acid and 3-chloro-4-propoxyphenol in an appropriate molar ratio.
2. Add a suitable solvent such as dichloromethane or methanol at room temperature.
3. Under appropriate conditions (such as heating and stirring), the reaction mixture is reacted.
4. After the end of the reaction, the product is filtered and dried to obtain calcium.

Safety Information:
-nor acid should be careful to avoid contact with eyes, skin and inhalation during use and storage. In case of accidental contact, rinse immediately with plenty of water and seek medical advice.
-Wear personal protective equipment such as lab gloves and goggles during operation.
-The process of preparing and handling the compound should be carried out under well-ventilated laboratory conditions to avoid the generation of harmful gases and vapors.
-When storing, it should be kept in a dry, cool place, away from fire and flammable substances.

Last Update：2024-04-10 22:29:15